Progress in drug metab v 9 progress in drug metabolism metabolism and toxicity of drugs two decades of progress the science of drug metabolism and pharmacokinetics dmpk has developed significantly over the past 20 years and its functional role in todays pharmaceutical industry has matured to. Carboxylesterases are a multi gene family of enzymes widely distributed throughout the body of mammals that catalyze the hydrolysis of esters amides thioesters and carbamates in humans two carboxylesterases hce1 and hce2 are important pathways of drug metabolism both are expressed in the
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